Publications

2024

2023

1. Nat Commun

   ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression

   Suyang Zhang, Feng Yang, Yile Huang, and 8 more authors

   Nature Communications, 2023

   Abs HTML

   Skeletal muscle stem cells (also called satellite cells, SCs) are important for maintaining muscle tissue homeostasis and damage-induced regeneration. However, it remains poorly understood how SCs enter cell cycle to become activated upon injury. Here we report that AP-1 family member ATF3 (Activating Transcription Factor 3) prevents SC premature activation. Atf3 is rapidly and transiently induced in SCs upon activation. Short-term deletion of Atf3 in SCs accelerates acute injury-induced regeneration, however, its long-term deletion exhausts the SC pool and thus impairs muscle regeneration. The Atf3 loss also provokes SC activation during voluntary exercise and enhances the activation during endurance exercise. Mechanistically, ATF3 directly activates the transcription of Histone 2B genes, whose reduction accelerates nucleosome displacement and gene transcription required for SC activation. Finally, the ATF3-dependent H2B expression also prevents genome instability and replicative senescence in SCs. Therefore, this study has revealed a previously unknown mechanism for preserving the SC population by actively suppressing precocious activation, in which ATF3 is a key regulator.

2. DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A/YTHDF1

   Yuwei Zhang, Jieyu Zhao, Xiaona Chen, and 5 more authors

   bioRxiv, 2023
3. In Vivo Investigation of Gene Function in Muscle Stem Cells by CRISPR/Cas9-Mediated Genome Editing

   Liangqiang He, Zhiming He, Yuying Li, and 2 more authors

   In Skeletal Muscle Stem Cells: Methods and Protocols, 2023
4. Multiscale 3D genome reorganization during skeletal muscle stem cell lineage progression and aging

   Yu Zhao, Yingzhe Ding, Liangqiang He, and 7 more authors

   Science Advances, 2023
5. Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export

   Yulong Qiao, Qiang Sun, Xiaona Chen, and 6 more authors

   Elife, 2023

2022

1. ATF3 Preserves Skeletal Muscle Stem Cell Quiescence by Preventing Precocious Activation

   Suyang Zhang, Yile Huang, Feng Yang, and 8 more authors

   bioRxiv, 2022

2010

1. Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus

   YM Dennis Lo, KC Allen Chan, Hao Sun, and 8 more authors

   Science translational medicine, 2010